| 货号 | 3352/50 |
| 别名 | 5E-4-Amino-6-(4-benzyloxy-3-chlorop |
| 供应商 | Tocris |
| 生物活性 | Potent and selective ErbB receptor family inhibitor (IC50 values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro(IC50 = 60 - 168 nM) and inhibits growth of human tumor xenografts in vivo. Brain penetrant and orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 519.42 |
| 分子式 | C24H27CIN6O3.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 944341-54-2 |
| 参考文献 | Contessa and Hamstra (2008) Revoking the privilege: targeting HER2 in the central nervous system. Mol.Pharmacol. 73 271. PMID: 17981994. Emanuelet al (2008) Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors. Mol.Pharmacol. 73 338. PMID: 17975007. Guessouset al (2008) Signaling pathways in medulloblastoma. J.Cell.Phys. 217577. |