| 货号 | 5068/50 |
| 别名 | 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-h |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of TGF-β signaling (IC50 = 0.85 μM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 415.52 |
| 分子式 | C27H29NO3 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO and to 10 mM in ethanol with gentle warming |
| 参考文献 | Kinneyet al (2013) Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis. Trends Biotechnol. 31 78. PMID: 23219200. Willemset al (2012) Small molecule-mediated TGF- |