| 货号 | 1047/50 |
| 别名 | 7α,17β-[9-[(4,4,5,5,5-Pentafluoropent |
| 供应商 | Tocris |
| 生物活性 | A high affinity estrogen receptor antagonist (IC50 = 0.29 nM), devoid of any partial agonism both in vitroandin vivo. Also high affinity agonist at the membrane estrogen receptor GPER. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 606.77 |
| 分子式 | C32H47F5O3S |
| 可溶性/溶解性 | Soluble to 50 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 129453-61-8 |
| 参考文献 | Thomaset al (2005) Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology. 146 624. PMID: 15539556. Howellet al (2000) ICI 182,780 (FaslodexTM): Development of a novel, "pure" antiestrogen. Cancer 89 817. PMID: 10951345. de Cupiset al (1995) Comparison between novel steroid-like and conventional nonsteroidal antioestrogens in inhibiting oestradiol and IGF-I induced proliferation of human breast cancer-derived cells. Br.J.Pharmacol. 116 2391. PMID: 8581274. Wakelinget al (1991) A potent specific pure antiestrogen with clinical potential. Cancer Res. 51 3867. PMID: 1855205. |