I-BRD9 (50 MG)
货号：
5591/50 基本售价：
12274.1 元 规格：
50 mg
产品信息
概述| 货号 | 5591/50 |
| 别名 | 5-Ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective BRD9 inhibitor (pIC50 = 7.3). Exhibits >70-fold selectivity for BRD9 over a panel of 34 other bromodomains and >700-fold selectivity over the BET family. Downregulates CLEC1,DUSP6,FESandSAMSN1 genes in Kasumi-1 cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 497.55 |
| 分子式 | C22H22F3N3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in 1eq. HCl |
| 参考文献 | Theodoulouet al (2015) Discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition. J.Med.Chem 59 1425. PMID: 25856009. |
