| 货号 | 5050/50 |
| 别名 | 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H- |
| 供应商 | Tocris |
| 生物活性 | Cdc42 GTPase inhibitor (IC50 = 2 μM). Reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs. Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo. Increases histone H4K16 acetylation in aged HSCs. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 306.4 |
| 分子式 | C20H22N2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Liet al (2013) Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 13 270. PMID: 24012368. Florianet al (2012) Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 10 520. PMID: 22560076. Petersonet al (2006) Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem.Biol. 13 443. PMID: 16632257. |