| 货号 | 2489/50 |
| 别名 | (2R*,3S*)-Tetrahydro-4-methylene-2- |
| 供应商 | Tocris |
| 生物活性 | Synthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitroandin vivo. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits anti-tumor activity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 254.32 |
| 分子式 | C14H22O4 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO |
| CAS号 | 191282-48-1 |
| 参考文献 | Takahashiet al (2004) The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator. Endocrinology 145 184. PMID: 14512433. Thupariet al (2004) Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. Am.J.Physiol.Endocrinol.Metab. 28797. Zhouet al (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 63 7330. PMID: 14612531. Kuhajdaet al (2000) Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc.Natl.Acad.Sci. 973450. |