| 货号 | 1441/50 |
| 别名 | 5-(Dimethylamino)-N-(3,4-dimethyl-5 |
| 供应商 | Tocris |
| 生物活性 | Potent, selective and competitive non-peptide endothelin ETA receptor antagonist (Ki = 48 nM). Displays > 1000-fold selectivity over ETB receptors. Inhibits ET-1-induced pressor response following oral or intravenous administration in vivo. Inhibits ET-1-induced longitudinal muscle contraction in the mouse colon in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 381.88 |
| 分子式 | C17H19N3O3S.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 153042-42-3 |
| 参考文献 | Khanet al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br.J.Pharmacol. 147 607. PMID: 16432510. Webbet al (1995) BMS-182874 is a selective, nonpeptide endothelin ETA receptor antagonist. J.Pharmacol.Exp.Ther. 272 1124. PMID: 7891325. Steinet al (1994) The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(Dimethylamino)-N-(3,4-dimethyl-5-isoazolyl)-1-naphthalenesulfonamide. J.Med.Chem. 37 329. PMID: 8308857. |