| 货号 | 4842/50 |
| 别名 | (3Z)-3-[[[3-[(Dimethylamino)methyl] |
| 供应商 | Tocris |
| 生物活性 | Selective MEK5 and ERK5 inhibitor (IC50 values are 1.5 and 59 nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 440.54 |
| 分子式 | C27H28N4O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl |
| 参考文献 | Lopez-Royuelaet al (2014) Extracellular-signal-regulated kinase 5 modulates the antioxidant response by transcriptionally controlling Sirtuin 1 expression in leukemic cells. Int.J.Biochem.Cell Biol. 53 253. PMID: 24880091. Kimuraet al (2010) Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart. Circ.Res. 106 961. PMID: 20075332. Tatakeet al (2008) Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem.Biophys.Res.Comm. 377 120. PMID: 18834865. |