| 货号 | 4608/50 |
| 别名 | 6-Chloro-9-[(4-methoxy-3,5-dimethyl |
| 供应商 | Tocris |
| 生物活性 | Selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro(EC50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 318.76 |
| 分子式 | C14H15ClN6O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Yinet al (2010) BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy. Int.J.Cancer 126 1216. PMID: 19662650. Lundgrenet al (2009) BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Mol.Cancer Ther. 8 921. PMID: 19372565. |