| 货号 | 4430/50 |
| 别名 | 5-Cyclopropyl-2-[1-[(2-fluorophenyl |
| 供应商 | Tocris |
| 生物活性 | Activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 360.39 |
| 分子式 | C20H17FN6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Joshiet al (2011) The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. J.Pharmacol.Exp.Ther. 339 394. PMID: 21825001. Staschet al (2010) NO-independent regulatory site on soluble guanylate cyclase. Nature 410 212. PMID: 11242081. Mittendorfet al (2009) Discovery of Riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension. ChemMedChem 4 853. PMID: 19263460. |