AZ 6102 ( )
货号：
5775/50 基本售价：
12274.1 元 规格：
50 mg
产品信息
概述| 货号 | 5775/50 |
| 别名 | rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one |
性能| 供应商 | Tocris |
| 生物活性 | Potent TNKS2 and TNKS1 inhibitor (IC50 values are 1 and 3 nM, respectively). Exhibits >100-fold selectivity for TNKS1/2 over PARP-1, PARP-2 and PARP-6. Inhibits Wnt signaling in DLD-1 cells (IC50 = 5 nM). Exhibits moderate oral bioavailability. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 428.53 |
| 分子式 | C25H28N6O |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Johanneset al (2015) Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. ACS Med.Chem.Lett. 13 254. PMID: 25815142. |
