| 货号 | 1107/50 |
| 别名 | (RS)-2-Amino-3-(3-hydroxy-5-tert-bu |
| 供应商 | Tocris |
| 生物活性 | A selective and potent GluR5 kainate receptor agonist (Ki = 4.3 nM), inactive at GluR6 (Ki > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (Ki values of 6 - 14 μM). Also available as part of the Kainate Receptor Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 228.25 |
| 分子式 | C10H16N2O4 |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 100 mM in 1eq. NaOH |
| CAS号 | 140158-50-5 |
| 参考文献 | Moldrichet al (1999) Excitotoxic injury profiles of low-affinity kainate receptor agonists in neuronal cultures. Eur.J.Pharmacol. 378 R1. PMID: 10478637. Clarkeet al (1997) A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 389 599. PMID: 9335499. Matzenet al (1997) AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazole bioisasteres of glutamic acid. J.Med.Chem. 40 520. PMID: 9046343. |