| 货号 | 4865/50 |
| 别名 | N2-1H-Benzimidazol-6-yl-N4-(5-cyclo |
| 供应商 | Tocris |
| 生物活性 | Allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 332.36 |
| 分子式 | C17H16N8 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl |
| 参考文献 | Wanget al (2012) Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat.Chem.Biol. 8 982. PMID: 23086298. Korennykhet al (2009) The unfolded protein response signals through high-order assembly of Ire1. Nature 457 687. PMID: 19079236. |