| 货号 | 1115/50 |
| 别名 | 1-(2,4-Dichlorophenyl)-5-(4-iodophe |
| 供应商 | Tocris |
| 生物活性 | Potent, selective CB1 cannabinoid receptor antagonist/inverse agonist (Ki values are 12 and 4200 nM for CB1 and CB2 receptors respectively). Increases locomotor activity following systemic administration in vivo. Analog of SR141716A (Ki = 14 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 557.22 |
| 分子式 | C21H19Cl2IN4O2 |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO with gentle warming |
| CAS号 | 202463-68-1 |
| 参考文献 | Cosenzaet al (2000) Locomotor activity and occupancy of brain cannabinoid CB1 receptors by the antagonist/inverse agonist AM281. Synapse 38 477. PMID: 11044895. Lanet al (1999) Design and synthesis of the CB1 selective cannabinoid antagonist AM281: a potential human SPECT ligand. AAPS Pharmsci. 1 E4. PMID: 11741201. Gatleyet al (1998) Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo. J.Neurochem. 70 417. PMID: 9422389. Giffordet al (1997) Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices. Neurosci.Lett. 238 84. PMID: 9464661. |