| 货号 | 4208/50 |
| 别名 | 5-Methoxy-N,N-dimethyl-1-(phenylsul |
| 供应商 | Tocris |
| 生物活性 | High affinity 5-HT6 antagonist (Ki = 2.1 nM). Potentiates the hypolocomotor actions of (-)-nicotine in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 448.49 |
| 分子式 | C19H22N2O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Nirogiet al (2010) Novel and potent 5-piperazinyl methyl-N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands. ACS Med.Chem.Lett. 1340. Dukatet al (2008) Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. J.Med.Chem. 51 603. PMID: 18201064. Younget al (2006) Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (-)nicotine. Pharmacol.Biochem.Behav. 85 170. PMID: 16950502. Glennonet al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011. PMID: 10715164. |