| 货号 | 3249/50 |
| 别名 | cis-(±)-1-Amino-3-phosphonocyclopent |
| 供应商 | Tocris |
| 生物活性 | Group III mGlu receptor agonist that exhibits higher potency at mGlu4 than mGlu8(EC50 values are 49 and 124 μM respectively) with no activity at mGlu7. Selectively inhibits synaptic activity in the lateral perforant pathway (IC50 values are 130 and 1859 μM in the lateral and medial perforant pathways respectively). Conformationally restrained analog of L-AP4 (Cat No. 0103). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 209.14 |
| 分子式 | C6H12NO5P |
| 可溶性/溶解性 | Soluble to 50 mM in 1.1eq. NaOH |
| CAS号 | 103439-17-4 |
| 参考文献 | Ayalaet al (2008) Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated. Neuropharmacology 54 804. PMID: 18255102. Joneset al (2008) Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract-piriform cortex synpase. Neuropharmacology 55 440. PMID: 18625254. Crookset al (1986) Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition of hippocampal excitatory transmission and displacement of [3H]APB binding. J.Med.Chem. 29 1988. PMID: 3020251. |