| 货号 | 2508/50 |
| 别名 | 1-[1-(Cyclooctylmethyl)-1,2,3,6-tet |
| 供应商 | Tocris |
| 生物活性 | Potent and selective nociceptin/orphanin FQ (NOP) receptor antagonist (pA2 = 7.75). Displays selectivity for NOP receptors over classical opioid receptors (pKi values are 8.65, 6.60, 6.14 and < 5 for NOP, μ-,κ-, and δ-opioid receptors respectively). Attenuates motor deficits in a rat model of Parkinson's Disease. Active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 434.02 |
| 分子式 | C24H35N3O2.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 873567-76-1 |
| 参考文献 | Martiet al (2008) The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction with L-DOPA. J.Neurochem. 107 1683. PMID: 19014386. Trapellaet al (2006) Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist. Bioorg.Med.Chem. 14 692. PMID: 16202610. |