| 货号 | 4336/50 |
| 别名 | (1Z)-1-(3-Ethyl-5-methoxy-2(3H)-ben |
| 供应商 | Tocris |
| 生物活性 | Potent, ATP-competitive inhibitor of Clk-family kinases (IC50 values are 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3). Also inhibits DYRK1A/B (IC50 values are 24 and 34 nM respectively). Suppresses serine/arginine-rich protein phosphorylation; affects the regulation of alternative splicing by phosphorylation of SR protein both in vitroandin vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 249.33 |
| 分子式 | C13H15NO2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 75 mM in ethanol |
| 参考文献 | Foucourtet al (2014) Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II. Molecules 19 15411. PMID: 25264830. Murakiet al (2004) Manipulation of alternative splicing by a newly developed inhibitor of Clks. J.Biol.Chem. 279 24246. PMID: 15010457. |