| 货号 | 2737/50 |
| 别名 | 4-(5-ethoxy-3-pyridinyl)-N-methyl-( |
| 供应商 | Tocris |
| 生物活性 | Subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC50 values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2,α4β4,α2β4,α3β4,α3β2 and α7 receptor subtypes respectively). Displays selectivity for (α4)2(β2)3 receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 438.43 |
| 分子式 | C12H18N2O. 2C4H4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 212332-35-9 |
| 参考文献 | Zwartet al (2006) 5-I A-85380 and TC-2559 differentially activate heterologously expressed α4β2 nicotinic receptors. Eur.J.Pharmacol. 539 10. PMID: 16674940. Chenet al (2003) The nicotinic α4β2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices. Neuropharmacology 45 334. PMID: 12871651. Bencherifet al (2000) TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors. Eur.J.Pharmacol. 409 45. PMID: 11099699. |