| 货号 | 1676/50 |
| 别名 | 1,2-Dihydro-2-[(2-methyl-4-pyridiny |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 620.06 |
| 分子式 | C31H29N5O7.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO with gentle warming |
| CAS号 | 324572-92-1 |
| 参考文献 | Mochidaet al (2004) T-0156, a novel phosphodiesterase type 5 inhibitor, and sildenafil have different pharmacological effects on penile tumescence and electroretinogram in dogs. Eur.J.Pharmacol. 485 283. PMID: 14757152. Mochidaet al (2002) Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur.J.Pharmacol. 456 91. PMID: 12450574. |