| 货号 | 0903/50 |
| 别名 | (2S,4R)-4-Methylglutamic acid |
| 供应商 | Tocris |
| 生物活性 | Potent and highly selective kainate receptor agonist, with an IC50 for inhibition of [3H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ and Kainate Receptor Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >97 % |
| 计算分子量 | 161.16 |
| 分子式 | C6H11NO4 |
| 可溶性/溶解性 | Soluble to 50 mM in water |
| CAS号 | 31137-74-3 |
| 参考文献 | Savidgeet al (1999) Characterisation of kainate receptor mediated whole-cell currents in rat cultured cerebellar granule cells. Neuropharmacology 38 375. PMID: 10219975. Donevanet al (1998) The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors. J.Pharmacol.Exp.Ther. 285 539. PMID: 9580595. Joneset al (1997) Desensitization of kainate receptors by kainate, glutamate and diastereomers of 4-methylglutamate. Neuropharmacology 36 853. PMID: 9225313. Zhouet al (1997) (2S,4R)-4-Methylglutamic acid (SYM 2081): a selective, high affinity ligand for kainate receptors. J.Pharmacol.Exp.Ther. 280 422. PMID: 8996224. |