| 货号 | 4409/50 |
| 别名 | 4'-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nit |
| 供应商 | Tocris |
| 生物活性 | Antidiabetic agent; binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPARγ agonist activity. Does not inhibit Cdk5-dependent phosphorylation of Rb. Reduces fasting insulin levels and improves insulin sensitivity in a mouse model of diabetes. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 547.6 |
| 分子式 | C33H29N3O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Norris and Sigmund (2012) A second chance for a PPARγ targeted therapy? Circ.Res. 110 8. PMID: 22223206. Choiet al (2011) Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature 477 477. PMID: 21892191. |