| 货号 | 5431/50 |
| 别名 | 2,6-Dihydro-7-[(3-hydroxypropyl)thi |
| 供应商 | Tocris |
| 生物活性 | Potent MCT1 inhibitor (IC50 = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro. Also inhibits lactate uptake in breast cancer cells in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 435.58 |
| 分子式 | C25H29N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Wanget al (2014) Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J.Med.Chem. 57 7317. PMID: 25068893. Murrayet al (2005) Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat.Chem.Biol. 1 371. PMID: 16370372. |