| 货号 | 5671/50 |
| 别名 | 6-Chloro-3-[[[(2,3-dichlorophenyl)a |
| 供应商 | Tocris |
| 生物活性 | Potent CXCR2 antagonist (IC50 = 7.7 nM). Exhibits 285-fold selectivity for CXCR2 over CXCR1. Reduces leukocyte numbers in synovial fluid in acute and chronic rabbit arthritis models. Also reduces synovial fluid eicosanoid and cytokine levels in a rabbit chronic arthritis model. Inhibits proliferation of AML cell lines in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 410.66 |
| 分子式 | C13H10Cl3N3< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Schinkeet al (2015) IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells. Blood 125 3144. PMID: 25810490. Podolinet al (2002) A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J.Immunol. 169 6435. PMID: 12444152. |