| 货号 | 1512/50 |
| 别名 | 4-Amino-5,6,7,8-tetrahydro-7-hydrox |
| 供应商 | Tocris |
| 生物活性 | GABAA receptor modulator; slows current decay. Potentiates α6,α3 and α5-subunit-containing receptors (EC50 values are 280, 695 and 730 nM respectively). Displays little effect on receptors containing α1 or α2 subunits. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 330.4 |
| 分子式 | C17H18N2O3S |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 100 mM in 1eq. HCl |
| CAS号 | 160296-13-9 |
| 参考文献 | Heidelberget al (2013) SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3,α5, or α6 subunit subtypes coexpressed with β3 and γ2 Subunits. J.Pharmacol.Exp.Ther. 347 235. PMID: 23902941. Hutcheonet al (2000) Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons. J.Physiol. 522 3. PMID: 10618148. Meadowset al (1998) SB-205384: a GABAA receptor modulator with novel mechanism of action that shows subunit selectivity. Br.J.Pharmacol. 123 1253. PMID: 9559912. Meadowset al (1997) Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum. Br.J.Pharmacol. 121 1334. PMID: 9257911. |