| 货号 | 2635/50 |
| 别名 | N-[4-[4-(2,3-Dichlorophenyl)-1-pipe |
| 供应商 | Tocris |
| 生物活性 | Potent and selective dopamine D3 receptor antagonist (Kivalues are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2,α1, D4, D1 and D5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 530.92 |
| 分子式 | C28H29Cl2N3O.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 189060-98-8 |
| 参考文献 | Pritchardet al (2007) The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacol.Biochem.Behav. 86 718. PMID: 17408730. Xiet al (2006) The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology 31 1393. PMID: 16205781. Yuanet al (1998) NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists. Bioorg.Med.Chem.Lett. 8 2715. PMID: 9873609. |