MSC 2032964A (50 MG)
货号：
5641/50 基本售价：
11381.8 元 规格：
50 mg
产品信息
概述| 货号 | 5641/50 |
| 别名 | N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective ASK1 inhibitor (IC50 = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 362.31 |
| 分子式 | C16H13F3N6 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO and to 10 mM in ethanol with gentle warming |
| 参考文献 | Guoet al (2010) Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol.Med. 2 504. PMID: 21064192. |
