ML 221 (50 MG)
货号：
4748/50 基本售价：
11381.8 元 规格：
50 mg
产品信息
概述| 货号 | 4748/50 |
| 别名 | 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one |
性能| 供应商 | Tocris |
| 生物活性 | Apelin receptor (APJ) antagonist (IC50 values are 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively). Displays >37-fold selectivity over the closely related angiotensin II type 1 (AT1) receptor. Exhibits no toxicity towards human hepatocytes at concentrations >50 μM. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 385.35 |
| 分子式 | C17H11N3O6 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Maloneyet al (2012) Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. Bioorg.Med.Chem.Lett. 22 6656. PMID: 23010269. |
