| 货号 | 4077/50 |
| 别名 | 3-[5-(3-(3-Fluorophenyl)-3-oxoprope |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of class IIa histone deacetylases (HDACs). Exhibits tissue-selective inhibition between members of class II deacetylases in vivo; inhibits HDAC4 and HDAC5 in skeletal muscle and the heart without affecting HDAC3 activity. Arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex. Displays no inhibition of class I HDAC activity or expression. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >96 % |
| 计算分子量 | 314.31 |
| 分子式 | C17H15FN2O3< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Nebbiosoet al (2009) Selective class II HDAC inhibitors may impaor myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. EMBO J. 10776. Maiet al (2007) Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia. Mol.Pharmacol. 72 1111. PMID: 17666592. Maiet al (2005) Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamines. J.Med.Chem. 48 3344. PMID: 15857140. |