| 货号 | 2387/50 |
| 别名 | 4-[[6-Methoxy-2-(4-methoxyphenyl)-3 |
| 供应商 | Tocris |
| 生物活性 | Potent CB1 receptor antagonist/inverse agonist (Ki = 141 nM) with greater than 70-fold selectivity over CB2 receptors (Ki > 10 μM). Structurally dissimilar from SR 141716A and AM 251. Shows weak binding to both 5-HT2(Ki = 6.4 μM) and muscarinic receptors (Ki = 2.1 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 383.4 |
| 分子式 | C24H17NO4 |
| 可溶性/溶解性 | Soluble to 30 mM in DMSO |
| CAS号 | 176977-56-3 |
| 参考文献 | Pertwee (2005) Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. Life Sci. 76 1307. PMID: 15670612. Hollandet al (1999) Cannabinoid CB1 receptors fail to cause relaxation, but couple via Gi/Go to the inhibition of adenylyl cyclase in carotid artery smooth muscle. Br.J.Pharmacol. 128 597. PMID: 10516638. Felderet al (1998) LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. J.Pharmacol.Exp.Ther. 284 291. PMID: 9435190. |