LY 2389575 hydrochloride (50 MG)
货号：
4969/50 基本售价：
11381.8 元 规格：
50 mg
产品信息
概述| 货号 | 4969/50 |
| 别名 | (3S)-N-(2,4-Dichlorobenzyl)-1-(5-bromopyrimidin-2-yl)pyrrolidinyl-3-amine hydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Selective negative allosteric modulator of mGlu3(IC50 = 190 nM). Exhibits > 65-fold selectivity for mGlu3 over other mGlu receptors. Abolishes the neuroprotective action of LY 379268 against amyloid β toxicity in mixed cortical neuronal and astrocyte cell cultures. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 438.58 |
| 分子式 | C15H15BrCl2N |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Caraciet al (2011) Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective. Mol.Pharmacol. 79 618. PMID: 21159998. |
