| 货号 | 0188/50 |
| 别名 | (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxad |
| 供应商 | Tocris |
| 生物活性 | Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect). Also available as part of the Group I mGlu Receptor Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 189.13 |
| 分子式 | C5H7N3O5 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. NaOH and to 10 mM in water |
| CAS号 | 52809-07-1 |
| 参考文献 | Littmanet al (1995) Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus. Neuropharmacology 34 829. PMID: 8532164. Schulteet al (1994) Utilization of the resolved L-isomer of 2-amino-6-phosphohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203. PMID: 7953634. Porteret al (1992) (S)-Homoquisqualate: a potent agonist at the glutamate metabotropic receptor. Br.J.Pharmacol. 106 509. PMID: 1324071. |