| 货号 | 1295/50 |
| 别名 | (Z)-1-[2-Chloro-2-(2,4-dichlorophen |
| 供应商 | Tocris |
| 生物活性 | Subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABAA receptor sensitization. Inhibits homomeric ρ1 GABACreceptors. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 311 |
| 分子式 | C10H6Cl3N3.HCl |
| 可溶性/溶解性 | Soluble to 5 mM in DMSO with gentle warming and to 5 mM in ethanol with gentle warming |
| CAS号 | 117857-45-1 |
| 参考文献 | Smithet al (2004) Compounds exhibiting selective efficacy for different β subunits of human recombinant γ-aminobutyric acidA receptors. J.Pharmacol.Exp.Ther. 311 601. PMID: 15210837. Fisheret al (2000) Loreclezole inhibition of recombinant α1β1γ2L GABAA receptor single channel currents. Neuropharmacology 39 235. PMID: 10670419. Thometet al (2000) Loreclezole as a simple functional marker for homomeric ρ type GABAC receptors. Eur.J.Pharmacol. 408 R1. PMID: 11080529. Donnelly and Macdonald (1996) Loreclezole enhances apparent desensitisation of recombinant GABAA receptor currents. Neuropharmacology 35 1233. PMID: 9014138. |