| 货号 | 5260/50 |
| 别名 | 2-(Methylthio)-6-[4-[5-[[3-(trifluo |
| 供应商 | Tocris |
| 生物活性 | PDGFRβ and B-Raf allosteric inhibitor. Also inhibits c-Raf, FLT3 and KIT. Disrupts blood vessel formation in zebrafish embryos and inhibits angiogenesis in a mouse angiogenesis model. Inhibits growth of renal and pancreatic tumors in mice. Also arrests cells in prometaphase. Orally available. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 459.45 |
| 分子式 | C20H16F3N7 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Mielgoet al (2011) A MEK-independent role for CRAF in mitosis and tumor progression. Nat.Med. 17 (1641). PMID: 22081024. Murphyet al (2010) Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc.Natl.Acad.Sci.U.S.A. 107 4299. PMID: 20154271. |