| 货号 | 3251/50 |
| 别名 | 3,4-Dimethoxy-N-methyl-N-[3-[(5-phe |
| 供应商 | Tocris |
| 生物活性 | Orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro(IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 449.99 |
| 分子式 | C22H27N3O3S.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 50 mM in DMSO |
| CAS号 | 181936-98-1 |
| 参考文献 | Letienneet al (2006) Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart. Eur.J.Pharmacol. 530 243. PMID: 16368090. Johnet al (2004) KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc.Drug Rev. 22 17. PMID: 14978516. Tamareilleet al (2002) Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels. J.Cardiovasc.Pharmacol. 40 346. PMID: 12198320. Deckinget al (1998) Cardioprotective actions of KC 12291. Naunyn-Schmied.Arch.Pharmacol. 358547. |