| 货号 | 1377/50 |
| 别名 | trans-3,4-dihydro-3-hydroxy-2,2-dim |
| 供应商 | Tocris |
| 生物活性 | Prototypical Kir6 (KATP) channel opener. Relaxes rabbit isolated portal vein with an IC50 value of 21 nM . Potent, orally active and hypotensive in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 286.33 |
| 分子式 | C16H18N2O3 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| CAS号 | 94470-67-4 |
| 参考文献 | Escandeet al (1988) The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes. Biochem.Biophys.Res.Commun. 154 620. PMID: 2456760. Longmanet al (1988) Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil. J.Cardiovasc.Pharmacol. 12 535. PMID: 2468052. Wilsonet al (1988) Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil. Eur.J.Pharmacol. 152 331. PMID: 2851450. |