SP 141 (50 MG)
货号：
5332/50 基本售价：
11233.1 元 规格：
50 mg
产品信息
概述| 货号 | 5332/50 |
| 别名 | 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole |
性能| 供应商 | Tocris |
| 生物活性 | High affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. Inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. Attenuates growth of breast cancer xenograft tumors. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 324.38 |
| 分子式 | C22H16N2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Wanget al (2014) The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat.Commun. 5 5086. PMID: 25271708. |
