| 货号 | 2074/50 |
| 别名 | 6-Chloro-2,3,4,5-tetrahydro-3-methy |
| 供应商 | Tocris |
| 生物活性 | Dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. Shown to potentiate agonist binding of the σ1receptor. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 398.73 |
| 分子式 | C18H20ClNO2.HBr |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 80751-85-5 |
| 参考文献 | Guoet al (2013) SKF83959 is a potent allosteric modulator of sigma-1 receptor. Mol.Pharmacol. 83 577. PMID: 23295385. Neumeyeret al (2003) Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur.J.Pharmacol. 474 137. PMID: 12921854. Coolset al (2002) SKF 83959 is an antagonist of dopamine D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals? Neuropharmacology 42 237. PMID: 11804620. Plattet al (2000) Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. J.Pharmacol.Exp.Ther. 293 1017. PMID: 10869406. |