| 货号 | 2910/50 |
| 别名 | N-[2-[[3-(4-Bromophenyl)-2-propenyl |
| 供应商 | Tocris |
| 生物活性 | Protein kinase A inhibitor that also inhibits several other kinases (IC50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b). Exhibits antinociceptive activity. Also available as part of the PKA TocrisetTM. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 519.28 |
| 分子式 | C20H20BrN3O2S.2HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 100 mM in DMSO |
| CAS号 | 127243-85-0 |
| 参考文献 | Lochner and Moolman (2006) The many faces of H89: a review. Cardiovasc.Drug Rev. 24 261. PMID: 17214602. Yamadaet al (2006) Involvement of cAMP response element-binding protein activation in salivary secretion. Pathobiology 73 1. PMID: 16785762. Vitoloet al (2002) Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proct.Natl.Acad.Sci.USA 99 13217. PMID: 12244210. Dolan and Nolan (2001) Biphasic modulation of nociceptive processing by the cyclic AMP-protein kinase A signalling pathway in sheep spinal cord. Neurosci.Lett. 309 157. PMID: 11514065. |