| 货号 | 5902/50 |
| 别名 | (1α,2β,4β,5α,7β)-7-[(2-Hydroxy-2,2-di-2- |
| 供应商 | Tocris |
| 生物活性 | Potent muscarinic receptor antagonist. Inhibits electrical field stimulation-induced contraction of guinea pig trachea in vitro(IC50 = 0.17 nM). Induces smooth muscle relaxation and bronchodilation. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 472.42 |
| 分子式 | C19H22BrNO4S |
| 可溶性/溶解性 | Soluble to 20 mM in water and to 100 mM in DMSO |
| 参考文献 | Smitet al (2014) Bronchoprotection by olodaterol is synergistically enhanced by tiotropium in a guinea pig model of allergic asthma. J.Pharmacol.Exp.Ther. 348 303. PMID: 24307202. Ogodaet al (2011) Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrrolate. J.Pharm.Sci. 115 374. PMID: 21358117. Takahashiet al (1994) Effect of Ba 679 BR, a novel long-acting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways. Am.J.Respir.Crit.Care Med. 150 1640. PMID: 7952627. |