Oxy-16
货号：
9000395-10mg 基本售价：
10976.0 元 规格：
10 mg
产品信息
概述| 货号 | 9000395-10mg |
| 描述 | Naturally occurring oxysterols are products of cholesterol oxidation that can stimulate the hedgehog (Hh) signaling pathway in target cells associated with cardiovascular disease and with bone formation.1 Depending on the target cell, activation of Hh signaling can modulate inflammatory responses to additional atherogenic factors such as lesion-producing macrophages or enable osteoblast differentiation.2,3 Oxy-16 is a synthetic oxysterol compound that may function as an antagonist of hedgehog activity. Published data regarding its efficacy remains forthcoming. |
| 别名 | 20(R),22(R)-dihydroxy Cholesterol; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dwyer, J.R.,Sever, N.,Carlson, M., et al. Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. The Journal of Biological Chemisty 282(12), 8959-8968 (2007).
2.Björkhem, I., and Diczfalusy, U. Oxysterols: Friends, foes, or just fellow passengers? Arteriosclerosis, Thrombosis, and Vascular Biology 22, 734-742 (2002).
3.Amantea, C.M.,Kim, W.K.,Meliton, V., et al. Oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by Dkk-1 inhibitable and PI3-kinase mediated signaling. Journal of Cellular Biochemistry 105(2), 424-436 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 418.7 |
| 分子式 | C27H46O3 |
| CAS号 | 596-94-1 |
| 稳定性 | ≥ 2 years |
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