AFP 07 (free acid)
货号：
13626-5mg 基本售价：
10976.0 元 规格：
5 mg
产品信息
概述| 货号 | 13626-5mg |
| 描述 | Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM).1 AFP 07 shows weaker affinity for EP receptors, with Ki values of > 100 nM for EP1-3 and > 10 nM for EP4.1 In piglet and rabbit saphenous veins, which express both IP and EP4, the EP4 antagonist AH 23848 reduces AFP 07-mediated relaxation, suggesting that AFP 07 activates EP4 as well as IP, particularly when both receptors are present.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chang, C.s.,Negishi, M.,Nakano, T., et al. 7,7-Difluoroprostacyclin derivative, AFP-07, a highly selective and potent agonist for the prostacyclin receptor. Prostaglandins 53, 83-90 (1997).
2.Jones, R.L., and Chan, K.m. Distinction between relaxations induced via prostanoid EP4 and IP1 receptors in pig and rabbit blood vessels. British Journal of Pharmacology 134, 313-324 (2001).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 412.5 |
| 分子式 | C22H30F2O5 |
| CAS号 | 788799-13-3 |
| 稳定性 | ≥ 1 year |
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