UNC0646
货号：
11085-50mg 基本售价：
10780.0 元 规格：
50 mg
产品信息
概述| 货号 | 11085-50mg |
| 描述 | G9a and G9a-like protein (GLP) are euchromatic histone-lysine methyltransferases (EHMT2 and EHMT1, respectively) that can heterodimerize with each other to methylate several proteins in addition to histone H3. UNC0646 is a potent and selective inhibitor of G9a and GLP activities in vitro(IC50s = 6 and 15 nM, respectively) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 26 nM).1 It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases.1 UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line.1 This compound selectively targets the corepressor function of G9a without affecting its ability to act as a coactivator with glucocorticoid receptor.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liu, F.,Barsyte-Lovejoy, D.,Allali-Hassani, A., et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. Journal of Medicinal Chemistry 54(17), 6139-6150 (2011).
2.Bittencourt, D.,Wu, D.Y.,Jeong, K.W., et al. G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes. Proceedings of the National Academy of Sciences of the United States of America 109(48), 19673-19678 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 621.9 |
| 分子式 | C36H59N7O2 |
| CAS号 | 1320288-17-2 |
| 稳定性 | ≥ 2 years |
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