LFM-A13
货号：
10010265-100mg 基本售价：
10780.0 元 规格：
100 mg
产品信息
概述| 货号 | 10010265-100mg |
| 描述 | Bruton’s tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating growth and differentiation of B cells. BTK acts as an inhibitor of Fas/APO-1-mediated apoptosis in B cells by preventing FAS-FADD interaction.1 LFM-A13 is an anti-leukemia agent with apoptosis-promoting and chemosensitizing properties.2,1 It acts as an inhibitor of Bruton’s tyrosine kinase (BTK) and Polo-like kinase (Plk) with IC50 values of 2.5 µM (mouse recombinant) and 10 µM (Xenopus), respectively.2,3 LFM-A13 exhibits minor inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and Cdk1, 2 and 3, as well as several other related kinases.2,3 LFM-A13 also exhibits anti-proliferative activity against HER2/Neu-overexpressing breast cancer cells.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Vassilev, A.,Ozer, Z.,Navara, C., et al. Bruton’s tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. The Journal of Biological Chemisty 274(3), 1646-1656 (1999).
2.Mahajan, S.,Ghosh, S.,Sudbeck, E.A., et al. Rational design and synthesis of a novel anti-leukemic agent targeting Bruton’s tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide]. The Journal of Biological Chemisty 274(14), 9587-9599 (1999).
3.Uckun, F.M.,Dibirdik, I.,Qazi, S., et al. Anti-breast cancer activity of LFM-A13, a potent inhibitor of polo-like kinase (PLK). Bioorganic & Medicinal Chemistry 15, 800-814 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 360 |
| 分子式 | C11H8Br2N2O2 |
| CAS号 | 244240-24-2 |
| 稳定性 | ≥ 2 years |
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