ZK118182 isopropyl ester
货号：
13673-500ug 基本售价：
10654.0 元 规格：
500 ug
产品信息
概述| 货号 | 13673-500ug |
| 描述 | Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2α and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM).1 ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sharif, N.A.,Williams, G.W.,Crider, J.Y., et al. Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes. Journal of Ocular Pharmacology and Therapeutics 20(6), 489-508 (2004).
2.Hellberg, M.R.,Conrow, R.E.,Sharif, N.A., et al. 3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents. Bioorganic & Medicinal Chemistry 10, 2031-2049 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 429 |
| 分子式 | C23H37ClO5 |
| CAS号 | 154927-31-8 |
| 稳定性 | ≥ 1 year |
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