BMN 673
货号：
19782-25mg 基本售价：
10584.0 元 规格：
25 mg
产品信息
概述| 货号 | 19782-25mg |
| 描述 | BMN 673 is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 value of 0.57 nM.1 It similarly binds to PARP1 and PARP2 with Ki values of 1.2 and 0.85 nM, respectively, but has no effect on PARG.1 BMN 673 selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene mutations and elicits antitumor activity in xenografted tumors in mice.1 |
| 别名 | Talazoparib; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Shen, Y.,Rehman, F.L.,Feng, Y., et al. BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency. Clin.Cancer.Res 19(18), 5003-5015 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 380.4 |
| 分子式 | C19H14F2N6O |
| CAS号 | 1207456-01-6 |
| 稳定性 | ≥ 2 years |
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