| 货号 | 1994/50 |
| 别名 | 4-(Methoxymethyl)-6-(phenylmethoxy) |
| 供应商 | Tocris |
| 生物活性 | Potent benzodiazepine receptor agonist (IC50 = 1 nM). Non-selective between α1-,α2-,α3- and α5-subunit containing GABAA receptors (Ki values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [3H]Ro15-1788 binding to human recombinant α1β3γ2,α2β3γ2,α3β3γ2 and α5β3γ2 receptors respectively). Anxiolytic following systemic administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 426.9 |
| 分子式 | C23H22N2O4.HCl |
| 可溶性/溶解性 | Soluble to 30 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 83910-44-5 |
| 参考文献 | Coxet al (1998) Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (ZK 93423) at wild type and recombinant GABAA receptors. J.Med.Chem. 41 2537. PMID: 9651158. File and Baldwin (1987) Effects of β-carbolines in animal models of anxiety. Brain Res.Bull. 19 293. PMID: 3315125. Stephenset al (1984) Discriminative stimulus properties of β-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors. Psychopharmacology 83 233. PMID: 6089245. |