| 货号 | 1211/50 |
| 别名 | 5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-t |
| 供应商 | Tocris |
| 生物活性 | A potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. Displaces [125I]-angiotensin II binding with an IC50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT1 antagonist, losartan. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 474.99 |
| 分子式 | C26H26N6O.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in water with gentle warming |
| CAS号 | 146709-78-6 |
| 参考文献 | Veelkenet al (1998) Endogenous angiotensin II and the reflex response to stimulation of cardiopulmonary serotonin 5HT3 receptors. Br.J.Pharmacol. 125 1761. PMID: 9886768. Junggrenet al (1996) Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat. J.Pharm.Pharmacol. 48 829. PMID: 8887734. Oldhamet al (1993) Zeneca ZD7155: a novel, potent and orally-effective angiotensin II receptor antagonist. Br.J.Pharmacol. 109P136. |