| 货号 | 3758/50 |
| 别名 | 8-Chlorodibenz(Z)[b,f][1,4]oxazepin |
| 供应商 | Tocris |
| 生物活性 | Selective EP1 prostanoid receptor antagonist (Ki values are 1.3, 11.2, 17.5, 61.1, > 100, > 100, > 100, >100 and > 100 μM for EP1, TP, EP3, EP2, EP4, FP and DP receptors respectively). Attenuates PGE2-induced neuronal cell death in vitro and slows tumor growth in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 459.33 |
| 分子式 | C22H19CIN4O3.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 146033-02-5 |
| 参考文献 | Saleemet al (2007) Effect of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice. J.Neurosci.Res. 85 2433. PMID: 17600836. Matsuoet al (2004) Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist. J.Neurochem. 66285. Abramovitzet al (2000) The utilization of recombinant prostanoid receptors determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 1483 285. PMID: 10634944. |