| 货号 | 4585/50 |
| 别名 | N-[[[3-Benzoylamino)phenyl]amino]th |
| 供应商 | Tocris |
| 生物活性 | Smoothened (Smo) receptor antagonist (IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo). Inhibits ShhN-induced Gli luciferase reporter activity in Shh-light 2 cells (IC50 = 2.5 μM); acts as an inverse agonist during nontranscriptional Hedgehog pathway activation (IC50 = 2.5 μM in HEK293 cells). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 465.52 |
| 分子式 | C24H23N3O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Solinaset al (2012) Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J.Med.Chem. 55 1559. PMID: 22268551. Manettiet al (2010) Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol.Pharmacol. 78 658. PMID: 20664000. |